Sodium Hydroxide → HCID 66631530, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(pyridin-2-yl)quinolin-6-yl)ethyl pivalate (45.2 mg, 0.085 mmol) in tetrahydrofuran and methanol (5:1, 1 mL) was added 1 M sodium hydroxide (2 mL) and the reaction was heated to 45° C. overnight. The reaction was cooled to room temperature, diluted with water and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate and concentrated. The crude extract was co-evaporated two times with acetonitrile to give a clear oil (33.8 mg). LCMS-ESI+ (m/z): [M+H]+ calcd for C27H28ClN2O2: 447.18. found: 447.72.

Provenance & Evidence