(Pyrimidin-5-yl)boronic acid → HCID 66631458, compound

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(S)-2-tert-Butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(pyrimidin-5-yl)quinolin-6-yl)acetic acid (87) was prepared following the procedure used for (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(1H-pyrazol-5-yl)quinolin-6-yl)acetic acid of Example 70 except that pyrimidin-5-ylboronic acid was used instead of 1H-pyrazol-5-ylboronic acid. 1H-NMR: 400 MHz, (CD3CN) δ: 9.52 (br s, 2 H), 9.26 (s, 1 H), 8.00 (s, 1H), 7.90 (d, J=8.8 Hz, 1 H), 7.83 (d, J=9.2 Hz, 1 H), 7.60 (m, 3 H), 7.37 (d, J=7.6 Hz, 1 H), 5.27 (s, 1 H), 2.65 9s, 3 H), 0.99 (s, 9 H). LCMS-ESI+ (m/z): [M+H]+ calcd for C26H25ClN3O3: 462.15. found: 462.45.

Provenance & Evidence