Sodium Hydroxide → HCID 66633557, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-7-methylquinolin-6-yl)ethyl pivalate (39.2 mg, 0.075 mmol) in tetrahydrofuran and methanol (5:1, 1 mL) was added 1 M sodium hydroxide (2 mL) and the reaction was heated to 45° C. overnight. The reaction was cooled to room temperature, diluted with water and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate and concentrated. The crude extract was co-evaporated two times with acetonitrile to give a clear white oil (32.1 mg). LCMS-ER+ (m/z): [M+H]+ calcd for C25H27ClN3O2: 436.17. found: 436.86.

Provenance & Evidence