Triacetoxyperiodinane → HCID 86691983, compound

Participants

Reaction Steps

To a solution of (S)-ethyl 2-(5-bromo-2-(hydroxymethyl)-7-methylquinolin-6-yl)-2-tert-butoxyacetate (200 mg, 0.49 mmol) in anhydrous dichloromethane (13 mL) at 0° C. was added Dess-Martin periodinane (248 mg, 0.58 mmol) and the reaction mixture was stirred for 1 hour. Reaction mixture was partitioned between dichloromethane and water and organic layer was concentrated and purified by flash column chromatography (silica gel, ethyl acetate/hexanes) to give a white solid (160 mg, 80%). LCMS-ESI+ (m/z): [M+H]+ calcd for C19H23BrNO4: 408.07. found: 408.88, 410.14

Provenance & Evidence