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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 931939Generated: October 29, 2026

Bromomethylcyclopropane → (3S,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-3-((5-methylisoxazol-3-yl)methyl)piperidin-2-one

https://huagongshe.com/reaction/931939

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBromomethylcyclopropaneHCID 81503—
Reactant3-(Bromomethyl)-5-methylisoxazoleHCID 2776304—
Reactant(5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)piperidin-2-oneHCID 58573791—
Product(3S,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-3-((5-methylisoxazol-3-yl)methyl)piperidin-2-oneHCID 56591174—

Reaction Steps

The title compound was prepared from (5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)piperidin-2-one (Example 1, Step E),3-(bromomethyl)-5-methylisoxazole, and (bromomethyl)cylopropane as described in Example 60.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09296736B2
Source datasetuspto-grants-2016_03
ORD IDord-c106ec79ecd241948994494ec5755f16
Source noteuspto-grants-2016_03