HCID 58573313, compound → HCID 58573812, compound

Participants

Reaction Steps

A solution of (3S,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(2,4-dimethoxybenzyl)-3-methyl-3-(methylthiomethyl)piperidin-2-one (Example 88, Step D) (0.406 g, 0.746 mmol) in TFA (6.00 mL) was heated at 50° C. under nitrogen for 2 hours. The reaction mixture was concentrated in vacuo to provide a purple oil. Purification using a 40 g SiO2 column and eluting with 35 to 60% EtOAc/hexanes provided the title compound as a white solid.

Provenance & Evidence