2-Chloro-4-methyl-5-nitropyridine → HCID 58573815, compound

HRID 932027Notes

Reaction equation

HRID 932027 reaction equation
[CH2:1]([C@@:4]1([CH3:25])[CH2:9][C@H:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[C@@H:7]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[NH:6][C:5]1=[O:24])[CH:2]=[CH2:3].Cl[C:27]1[CH:32]=[C:31]([CH3:33])[C:30]([N+]([O-])=O)=[CH:29][N:28]=1>>[CH2:1]([C@@:4]1([CH3:25])[CH2:9][C@H:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[C@@H:7]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[N:6]([C:27]2[CH:32]=[C:31]([CH3:33])[CH:30]=[CH:29][N:28]=2)[C:5]1=[O:24])[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 3453642-Chloro-4-methyl-5-nitropyridineHCID 58574008(3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methylpiperidin-2-one

Product 1

HCID 58573815HCID 58573815, compound

Procedure

The title compound was prepared from (3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methylpiperidin-2-one (Example 71, Step D) and 2-chloro-4-methyl-5-nitropyridine as described in Example 113 Steps A-C to provide a white solid.

Workup

  1. customto provide a white solid

Sources & evidence

ORD record
ord-21a490d74227443590247e5687e0fada
Source dataset
uspto-grants-2016_03
Patent number
US09296736B2

Reaction notes

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