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HRID932163

反应详情

EQUATION

反应方程式

HRID 932163 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

结构：CN.Cl
HCID6364545

未命名化合物

结构：CC[C@@H](C=O)N1C(=O)[C@@](C)(CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1
HCID58573880

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@@H](CNC)N1C(=O)[C@@](C)(CC(=O)[O-])C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1.[NH4+]
HCID68000924

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

3
结构：ClCCCl
溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

结构：CO
溶剂HCID887

Methanol

CH4O

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-oxobutan-2-yl)piperidin-3-yl)acetic acid (201 mg, 0.434 mmol; Example 210 Step A) in DCE (3 mL) was added methylamine hydrochloride (117 mg, 1.736 mmol) followed by sodium triacetoxyborohydride (184 mg, 0.868 mmol). After 4 hours, the mixture was diluted with methanol and DCM, filtered, and concentrated. The residue was purified by flash chromatography on silica gel (eluent: 20-100% ethylacetate/hexanes followed by 6:1:0.1 DCM:MeOH:NH4OH) to afford the title compound.

WORKUP

后处理

  1. filtrationfiltered
  2. concentrationconcentrated
  3. customThe residue was purified by flash chromatography on silica gel (eluent: 20-100% ethylacetate/hexanes followed by 6:1:0.1 DCM:MeOH:NH4OH)