Cyclopropanesulfonamide → HCID 68000393, compound

HRID 932203Notes

Reaction equation

[CH2:1]([C@@:4]1([CH2:31][CH3:32])[CH2:9][C@H:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[C@@H:7]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[N:6]([C@@H:24]([CH:27]2[CH2:29][CH2:28]2)[CH2:25]O)[C:5]1=[O:30])[CH:2]=[CH2:3].[CH:33]1([S:36]([NH2:39])(=[O:38])=[O:37])[CH2:35][CH2:34]1>>[CH2:1]([C@@:4]1([CH2:31][CH3:32])[CH2:9][C@H:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[C@@H:7]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[N:6]([C@@H:24]([CH:27]2[CH2:29][CH2:28]2)[CH2:25][NH:39][S:36]([CH:33]2[CH2:35][CH2:34]2)(=[O:38])=[O:37])[C:5]1=[O:30])[CH:2]=[CH2:3]

Participants

Reactant 2

HCID 15765418Cyclopropanesulfonamide

HCID 58573559HCID 58573559, compound

Product 1

HCID 68000393HCID 68000393, compound

Procedure

(3S,5R,6S)-3-Allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-hydroxyethyl)-3-ethylpiperidin-2-one (Example 253, Step C,) was coupled with cyclopropanesulfonamide by the procedure described in example 202, step C to afford the title compound as a white foam.

Sources & evidence

ORD record: ord-0b9992ea2c984620971c1916fb548b10
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09296736B2

Reaction notes

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