2-Thiophenesulfonamide → HCID 67998722, compound

HRID 932221Notes

Reaction equation

HRID 932221 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:8]2[C@@H:13]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[N:12]([C@@H:21]([CH:24]3[CH2:26][CH2:25]3)[CH2:22]O)[C:11](=[O:27])[C@:10]([CH2:29][C:30]([O:32]C)=[O:31])([CH3:28])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.S1C=CC=C1S(N)(=O)=O.[Cl:43][C:44]1[S:48][C:47]([S:49]([NH2:52])(=[O:51])=[O:50])=[CH:46][CH:45]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:8]2[C@@H:13]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[N:12]([C@@H:21]([CH:24]3[CH2:26][CH2:25]3)[CH2:22][NH:52][S:49]([C:47]3[S:48][C:44]([Cl:43])=[CH:45][CH:46]=3)(=[O:51])=[O:50])[C:11](=[O:27])[C@:10]([CH2:29][C:30]([OH:32])=[O:31])([CH3:28])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 728812-ThiophenesulfonamideHCID 12413015-Chlorothiophene-2-SulfonamideHCID 67999735HCID 67999735, compound

Product 1

HCID 67998722HCID 67998722, compound

Procedure

The title compound was prepared from methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-hydroxyethyl)-3-methyl-2-oxopiperidin-3-yl)acetate (Example 263, Step C) by procedures similar to those described in Example 263, Step D and E, substituting thiophene-2-sulfonamide in Step D with the appropriate amount of 5-chlorothiophene-2-sulfonamide.

Sources & evidence

ORD record
ord-12465dba5ba34c48bba0b4ef18bae1df
Source dataset
uspto-grants-2016_03
Patent number
US09296736B2

Reaction notes

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