Sodium ethanethiolate → HCID 58573856, compound

HRID 932240Notes

Reaction equation

CS([O-])(=O)=O.[CH2:6]([C@@:9]1([CH2:35][CH3:36])[CH2:14][C@H:13]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[CH:16]=2)[C@@H:12]([C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)[N+:11]2[C@@H:29]([CH:32]3[CH2:34][CH2:33]3)[CH2:30][O:31][C:10]1=2)[CH:7]=[CH2:8].[CH2:37]([S-:39])[CH3:38].[Na+]>>[CH2:6]([C@@:9]1([CH2:35][CH3:36])[CH2:14][C@H:13]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[CH:16]=2)[C@@H:12]([C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)[N:11]([C@@H:29]([CH:32]2[CH2:34][CH2:33]2)[CH2:30][S:39][CH2:37][CH3:38])[C:10]1=[O:31])[CH:7]=[CH2:8]

Participants

Reactant 2

HCID 4459711Sodium ethanethiolate

HCID 86660744HCID 86660744, compound

Product 1

HCID 58573856HCID 58573856, compound

Procedure

The title compound was prepared from (3S,5S,6R,8S)-8-Allyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-cyclopropyl-8-ethyl-2,3,5,6,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium methanesulfonate (Example 357, Step A) and sodium ethanethiolate by the method described in Example 339.

Sources & evidence

ORD record: ord-d8860fce52834fdc94a35a432e839d6f
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09296736B2

Reaction notes

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