N,N-Dimethylsulfamide → HCID 67998624, compound

HRID 932251Notes

Reaction equation

HRID 932251 reaction equation
[CH2:1]([C@@:4]1([CH3:31])[CH2:9][C@H:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[C@@H:7]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[N:6]([C@@H:24]([CH:27]2[CH2:29][CH2:28]2)[CH2:25]O)[C:5]1=[O:30])[CH:2]=[CH2:3].[CH3:32][N:33]([CH3:38])[S:34]([NH2:37])(=[O:36])=[O:35]>>[Cl:16][C:12]1[CH:11]=[C:10]([C@@H:8]2[C@@H:7]([C:17]3[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=3)[N:6]([C@@H:24]([CH:27]3[CH2:29][CH2:28]3)[CH2:25][NH:37][S:34](=[O:36])(=[O:35])[N:33]([CH3:38])[CH3:32])[C:5](=[O:30])[C@@:4]([CH3:31])([CH2:1][CH:2]=[CH2:3])[CH2:9]2)[CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 134472N,N-DimethylsulfamideHCID 58573730HCID 58573730, compound

Product 1

HCID 67998624HCID 67998624, compound

Procedure

The title compound was prepared from (3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-hydroxyethyl)-3-methylpiperidin-2-one (Example 252, Step A) and N,N-dimethylsulfamide (TCI America, Portland, Oreg.) following a procedure similar to the one described in Example 202, Step C.

Sources & evidence

ORD record
ord-cfc0bff9aebb4bc38386a71c79622552
Source dataset
uspto-grants-2016_03
Patent number
US09296736B2

Reaction notes

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