Methyl iodide → HCID 58573290, compound

HRID 932297Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:8]2[C@@H:13]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[N:12]([N:21]([CH2:24]C)[CH2:22]C)[C:11](=[O:26])[C@:10]([CH2:28][C:29]([O:31]C)=[O:30])([CH3:27])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.CI>>[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:8]2[C@@H:13]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[N:12]([N:21]([CH3:22])[CH3:24])[C:11](=[O:26])[C@:10]([CH2:28][C:29]([OH:31])=[O:30])([CH3:27])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 58573996HCID 58573996, compound

Product 1

HCID 58573290HCID 58573290, compound

Procedure

Methyl 2-((3R,5R,6S)-1-amino-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetate (Example 429 step C) was treated by a procedure similar to the one described in Example 429, using methyl iodide instead of ethyl iodide in Step C.

Sources & evidence

ORD record: ord-3c7bc493d10a45c2bba51065a4f79306
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09296736B2

Reaction notes

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