Bromide ion → tert-butyl 3-(5-methyl-2-pyridinyl)-5-(5-pyridin-2-yl-4,5-dihydro-1,2-oxazol-3-yl)benzoate

HRID 932419Notes

Reaction equation

HRID 932419 reaction equation
[Br-:26].[Br:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[O:7][C:8]([CH3:9])([CH3:10])[CH3:11])[cH:12][c:13]([C:15]2=[N:16][O:17][CH:18]([c:20]3[n:21][cH:22][cH:23][cH:24][cH:25]3)[CH2:19]2)[cH:14]1.[CH2:38]([N:39]([CH2:40][C:41]([OH:42])=[O:43])[CH2:44][C:45]([OH:46])=[O:47])[CH2:48][N:49]([CH2:50][C:51]([OH:52])=[O:53])[CH2:54][C:55]([OH:56])=[O:57].[CH3:27][c:28]1[cH:29][cH:30][c:31]([Zn+:34])[n:32][cH:33]1.[Cl:58][CH2:59][Cl:60].[K:35].[K:36].[K:37].[O:61]1[CH2:62][CH2:63][O:64][CH2:65][CH2:66]1>>[c:2]1(-[c:31]2[cH:30][cH:29][c:28]([CH3:27])[cH:33][n:32]2)[cH:3][c:4]([C:5](=[O:6])[O:7][C:8]([CH3:9])([CH3:10])[CH3:11])[cH:12][c:13]([C:15]2=[N:16][O:17][CH:18]([c:20]3[n:21][cH:22][cH:23][cH:24][cH:25]3)[CH2:19]2)[cH:14]1

Participants

8

Reactant 7

HCID 259Bromide ionHCID 6049Ethylenediaminetetraacetic AcidHCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 5462222Potassium3×HCID 68678078tert-Butyl 3-bromo-5-(5-(pyridin-2-yl)-4,5-dihydroisoxazol-3-yl)benzoateHCID 178427807HCID 178427807, compound

Product 1

HCID 178423800tert-butyl 3-(5-methyl-2-pyridinyl)-5-(5-pyridin-2-yl-4,5-dihydro-1,2-oxazol-3-yl)benzoate

Sources & evidence

ORD record
ord-0e4226e05331477eaea31b0b264bb10c
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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