1-Bromo-4-(bromomethyl)-2-fluorobenzene → 6-(4-bromo-3-fluorobenzylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine
Reaction equation
[Br:26][c:27]1[c:28]([F:35])[cH:29][c:30]([CH2:33][Br:34])[cH:31][cH:32]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][c:11]2[c:12]([c:15]([S:20][C:21](=[O:22])[N:23]([CH3:24])[CH3:25])[c:16]([Cl:19])[cH:17][cH:18]2)[CH2:13][CH2:14]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][c:11]2[c:12]([c:15]([S:20][CH2:21][c:30]3[cH:29][c:28]([F:35])[c:27]([Br:26])[cH:32][cH:31]3)[c:16]([Cl:19])[cH:17][cH:18]2)[CH2:13][CH2:14]1Participants
3
Sources & evidence
- ORD record
- ord-728419faa6384e9ca3d3f8d20cf7dca5
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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