Ethanol → Ethyl 5-(2,4-difluorophenyl)-3-iodo-salicylate

HRID 933463Notes

Reaction equation

HRID 933463 reaction equation
[CH2:24]([CH3:25])[OH:26].[F:5][c:6]1[c:7](-[c:13]2[cH:14][c:15]([I:23])[c:16]([OH:22])[c:17]([C:18](=[O:19])[OH:20])[cH:21]2)[cH:8][cH:9][c:10]([F:12])[cH:11]1.[S:1]([Cl:2])([Cl:3])=[O:4]>>[F:5][c:6]1[c:7](-[c:13]2[cH:14][c:15]([I:23])[c:16]([OH:22])[c:17]([C:18](=[O:19])[O:20][CH2:24][CH3:25])[cH:21]2)[cH:8][cH:9][c:10]([F:12])[cH:11]1

Participants

4

Reactant 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 43695632',4'-Difluoro-4-hydroxy-5-iodo-1,1'-biphenyl-3-carboxylic acid

Product 1

HCID 11407027Ethyl 5-(2,4-difluorophenyl)-3-iodo-salicylate

Sources & evidence

ORD record
ord-ea57ee9eaab44754bc182ba143ef78a9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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