6-[[3-[[4-(2-Aminoethyl)phenyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide → 6-((3-((2-(4-(2-Aminoethyl)phenoxy)ethyl)(methyl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide

HRID 933468Notes

Reaction equation

[C:45]([NH2:46])(=[O:47])[c:48]1[cH:49][n:50][c:51]2[c:52]([CH3:99])[cH:53][c:54]([S:67](=[O:68])(=[O:69])[c:70]3[cH:71][c:72]([C:73](=[O:74])[N:75]([CH3:76])[CH2:77][CH2:78][O:79][c:80]4[cH:81][cH:82][c:83]([CH2:84][CH2:85][NH:86][C:87](=[O:88])[O:89][C:90]([CH3:91])([CH3:92])[CH3:93])[cH:94][cH:95]4)[cH:96][cH:97][cH:98]3)[cH:55][c:56]2[c:57]1[NH:58][c:59]1[cH:60][c:61]([O:65][CH3:66])[cH:62][cH:63][cH:64]1.[NH2:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([NH:8][C:9]([c:10]2[cH:11][c:12]([S:13]([c:14]3[cH:15][c:16]4[c:17]([c:18]([CH3:19])[cH:20]3)[n:21][cH:22][c:23]([C:24]([NH2:25])=[O:26])[c:27]4[NH:28][c:29]3[cH:30][cH:31][cH:32][c:33]([O:34][CH3:35])[cH:36]3)(=[O:37])=[O:38])[cH:39][cH:40][cH:41]2)=[O:42])[cH:43][cH:44]1>>[C:45]([NH2:46])(=[O:47])[c:48]1[cH:49][n:50][c:51]2[c:52]([CH3:99])[cH:53][c:54]([S:67](=[O:68])(=[O:69])[c:70]3[cH:71][c:72]([C:73](=[O:74])[N:75]([CH3:76])[CH2:77][CH2:78][O:79][c:80]4[cH:81][cH:82][c:83]([CH2:84][CH2:85][NH2:86])[cH:94][cH:95]4)[cH:96][cH:97][cH:98]3)[cH:55][c:56]2[c:57]1[NH:58][c:59]1[cH:60][c:61]([O:65][CH3:66])[cH:62][cH:63][cH:64]1

Participants

Reactant 2

HCID 585050736-[[3-[[4-(2-Aminoethyl)phenyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

HCID 66987981tert-butyl 4-(2-(3-((3-carbamoyl-4-((3-methoxyphenyl)amino)-8-methylquinolin-6-yl)sulfonyl)-N-methylbenzamido)ethoxy)phenethylcarbamate

Product 1

HCID 669883066-((3-((2-(4-(2-Aminoethyl)phenoxy)ethyl)(methyl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide

Sources & evidence

ORD record: ord-9828955e9d9c49b389e6e1cc06dfd994
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…