Benzene → Tert-butyl 4-[2-[4-[3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl]phenyl]ethenyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

HRID 934062Notes

Reaction equation

HRID 934062 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[C:9]([CH3:22])([CH3:23])[O:10][CH2:11][CH:12]1[CH:13]=[CH:14][c:15]1[cH:16][cH:17][c:18]([I:21])[cH:19][cH:20]1.[C:37](=[O:38])([O-:39])[O-:40].[CH:51](=[CH:52][C:53]([CH:54]=[CH:55][c:56]1[cH:57][cH:58][cH:59][cH:60][cH:61]1)=[O:62])[c:63]1[cH:64][cH:65][cH:66][cH:67][cH:68]1.[Cs+:41].[Cs+:42].[Cu+:89].[F:24][c:25]1[cH:26][cH:27][c:28]([N:31]2[C:32](=[O:36])[NH:33][CH2:34][CH2:35]2)[cH:29][cH:30]1.[NH2:43][CH:44]1[CH2:45][CH2:46][CH2:47][CH2:48][CH:49]1[NH2:50].[O:69]1[CH2:70][CH2:71][O:72][CH2:73][CH2:74]1.[S:81]([O-:82])([C:83]([F:84])([F:85])[F:86])(=[O:87])=[O:88].[cH:75]1[cH:76][cH:77][cH:78][cH:79][cH:80]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[C:9]([CH3:22])([CH3:23])[O:10][CH2:11][CH:12]1[CH:13]=[CH:14][c:15]1[cH:16][cH:17][c:18]([N:33]2[C:32](=[O:36])[N:31]([c:28]3[cH:27][cH:26][c:25]([F:24])[cH:30][cH:29]3)[CH2:35][CH2:34]2)[cH:19][cH:20]1

Participants

11

Reactant 10

HCID 241BenzeneHCID 46101,2-DiaminocyclohexaneHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 95417Dibenzylidene acetoneHCID 104815Copper(1+)HCID 104967Cesium cation2×HCID 14807851-(4-Fluorophenyl)imidazolidin-2-oneHCID 2758875TrifluoromethanesulfonateHCID 67151624HCID 67151624, compound

Product 1

HCID 67151535Tert-butyl 4-[2-[4-[3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl]phenyl]ethenyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Sources & evidence

ORD record
ord-18a92cf185b7482b882d6060c945f10b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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