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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 934528Generated: October 30, 2026

Toluene → 2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-N-[5-(3-hydroxyprop-1-ynyl)pyrazin-2-yl]propanamide

https://huagongshe.com/reaction/934528

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTolueneHCID 1140—
ReactantPropargyl alcoholHCID 7859—
ReactantTriphenylphosphineHCID 11776—
ReactantPalladium ChlorideHCID 24290—
ReactantCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
ReactantDiisopropylethylamineHCID 81531—
ReactantN-(5-bromo-pyrazin-2-yl)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamideHCID 21897386—
Product2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-N-[5-(3-hydroxyprop-1-ynyl)pyrazin-2-yl]propanamideHCID 67482381—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-e9f2372282904b559e9ede02d8455451
Source noteValidation data from https://doi.org/10.1039/C8SC04228D