1,3-Oxazol-2(5H)-one → 3-{4-[4-(5-Cyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3,5-difluorophenyl}oxazolidin-2-one
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:26])[c:5]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][N:14]([c:17]3[n:18][cH:19][c:20]([CH:23]4[CH2:24][CH2:25]4)[cH:21][cH:22]3)[CH2:15][CH2:16]2)[c:6]([F:8])[cH:7]1.[O:27]1[C:28](=[O:32])[N:29]=[CH:30][CH2:31]1>>[c:2]1([N:29]2[C:28](=[O:32])[O:27][CH2:31][CH2:30]2)[cH:3][c:4]([F:26])[c:5]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][N:14]([c:17]3[n:18][cH:19][c:20]([CH:23]4[CH2:24][CH2:25]4)[cH:21][cH:22]3)[CH2:15][CH2:16]2)[c:6]([F:8])[cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-88ab6a4d96b349478949b2fbbada90b6
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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