Methanol → tert-butyl (1RS,2SR)-2-hydroxy-2-[4-(pyridin-2-yloxy)phenyl]-1-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]ethylcarbamate

HRID 93486Notes

Reaction equation

HRID 93486 reaction equation
[CH3:44][OH:45].[Na+:42].[O:1]=[C:2]1[O:3][CH:4]([c:28]2[cH:29][cH:30][c:31]([O:34][c:35]3[n:36][cH:37][cH:38][cH:39][cH:40]3)[cH:32][cH:33]2)[CH:5]([CH2:14][c:15]2[cH:16][c:17]([O:21][C:22]([CH:23]([F:24])[F:25])([F:26])[F:27])[cH:18][cH:19][cH:20]2)[N:6]1[C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13].[OH-:41].[OH2:43]>>[OH:3][CH:4]([CH:5]([NH:6][C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:14][c:15]1[cH:16][c:17]([O:21][C:22]([CH:23]([F:24])[F:25])([F:26])[F:27])[cH:18][cH:19][cH:20]1)[c:28]1[cH:29][cH:30][c:31]([O:34][c:35]2[n:36][cH:37][cH:38][cH:39][cH:40]2)[cH:32][cH:33]1

Participants

6

Reactant 5

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 86593275tert-butyl (4RS,5SR)-2-oxo-5-[4-(pyridin-2-yloxy)phenyl]-4-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-1,3-oxazolidine-3-carboxylate

Product 1

HCID 86593276tert-butyl (1RS,2SR)-2-hydroxy-2-[4-(pyridin-2-yloxy)phenyl]-1-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]ethylcarbamate

Sources & evidence

ORD record
ord-1bc7b6823b1047e9a4295a10d51a3dca
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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