2-Chloro-5-hydroxypyridine → cis-[4-(6-Chloro-pyridin-3-yloxy)-cyclohexyl]-(4-cyclobutyl-piperazin-1-yl)-methanone

HRID 935295Notes

Reaction equation

HRID 935295 reaction equation
[CH:1]1([N:5]2[CH2:6][CH2:7][N:8]([C:11](=[O:12])[CH:13]3[CH2:14][CH2:15][CH:16]([OH:19])[CH2:17][CH2:18]3)[CH2:9][CH2:10]2)[CH2:2][CH2:3][CH2:4]1.[Cl:20][c:21]1[n:22][cH:23][c:24]([OH:27])[cH:25][cH:26]1>>[CH:1]1([N:5]2[CH2:6][CH2:7][N:8]([C:11](=[O:12])[CH:13]3[CH2:14][CH2:15][CH:16]([O:19][c:24]4[cH:23][n:22][c:21]([Cl:20])[cH:26][cH:25]4)[CH2:17][CH2:18]3)[CH2:9][CH2:10]2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 8198212-Chloro-5-hydroxypyridineHCID 57538854cis-(4-Cyclobutyl-piperazin-1-yl)-(4-hydroxy-cyclohexyl)-methanone

Product 1

HCID 25124348cis-[4-(6-Chloro-pyridin-3-yloxy)-cyclohexyl]-(4-cyclobutyl-piperazin-1-yl)-methanone

Sources & evidence

ORD record
ord-fac67280a1014830bacbb67c116b1ba4
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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