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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 935587Generated: October 30, 2026

Trifluoroacetic acid → rac-(2'S,3'R,4'S,5'R)-6-bromo-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-cyano-phenyl)-amide

https://huagongshe.com/reaction/935587

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant4-AminobenzonitrileHCID 13396—
ReactantDiphenylphosphinic chlorideHCID 73910—
ReactantDiisopropylethylamineHCID 81531—
Reactant6-bromo-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxylic acidHCID 76741087—
Productrac-(2'S,3'R,4'S,5'R)-6-bromo-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-cyano-phenyl)-amideHCID 75986406—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-6eecea0e690c477e934d561fbc566b77
Source noteValidation data from https://doi.org/10.1039/C8SC04228D