2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol → 3-(2-(6-(4-(2-Hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzenesulfonamide

HRID 935958Notes

Reaction equation

HRID 935958 reaction equation
[Cl:22][c:23]1[cH:24][c:25]([N:30]2[CH2:31][CH2:32][N:33]([CH2:36][CH2:37][OH:38])[CH2:34][CH2:35]2)[n:26][c:27]([CH3:29])[n:28]1.[NH2:1][c:2]1[n:3][cH:4][c:5]2[c:6]([n:7]1)[c:8](-[c:11]1[cH:12][c:13]([S:17](=[O:18])(=[O:19])[NH:20][CH3:21])[cH:14][cH:15][cH:16]1)[cH:9][s:10]2>>[NH:1]([c:2]1[n:3][cH:4][c:5]2[c:6]([n:7]1)[c:8](-[c:11]1[cH:12][c:13]([S:17](=[O:18])(=[O:19])[NH:20][CH3:21])[cH:14][cH:15][cH:16]1)[cH:9][s:10]2)[c:23]1[cH:24][c:25]([N:30]2[CH2:31][CH2:32][N:33]([CH2:36][CH2:37][OH:38])[CH2:34][CH2:35]2)[n:26][c:27]([CH3:29])[n:28]1

Participants

3

Reactant 2

HCID 144795582-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanolHCID 671201393-(2-aminothieno[3,2-d]pyrimidin-7-yl)-N-methylbenzenesulfonamide

Product 1

HCID 529318963-(2-(6-(4-(2-Hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzenesulfonamide

Sources & evidence

ORD record
ord-fd3a44774ff04cf280573ccb879f9b2d
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…