(Pyrimidin-5-yl)boronic acid → 4-Fluoro-1-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-1-(pyridin-4-yl)-1H-isoindol-3-amine

HRID 936357Notes

Reaction equation

HRID 936357 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:9]2([c:20]3[cH:21][cH:22][n:23][cH:24][cH:25]3)[N:10]=[C:11]([NH2:19])[c:12]3[c:13]([F:18])[cH:14][cH:15][cH:16][c:17]32)[cH:5][cH:6][c:7]1[F:8].[n:26]1[cH:27][n:28][cH:29][c:30]([B:32]([OH:33])[OH:34])[cH:31]1>>[c:2]1(-[c:30]2[cH:29][n:28][cH:27][n:26][cH:31]2)[cH:3][c:4]([C:9]2([c:20]3[cH:21][cH:22][n:23][cH:24][cH:25]3)[N:10]=[C:11]([NH2:19])[c:12]3[c:13]([F:18])[cH:14][cH:15][cH:16][c:17]32)[cH:5][cH:6][c:7]1[F:8]

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 585794771-(3-Bromo-4-fluorophenyl)-4-fluoro-1-(pyridin-4-yl)-1H-isoindol-3-amine

Product 1

HCID 462062954-Fluoro-1-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-1-(pyridin-4-yl)-1H-isoindol-3-amine

Sources & evidence

ORD record
ord-bded4c7ebc8d474cb6b1f8bdf2452cb9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…