5-(Propan-2-yl)-1,3-oxazole-4-carboxylic acid → N-[3-(2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl)-4-fluorophenyl]-5-propan-2-yl-1,3-oxazole-4-carboxamide

HRID 936487Notes

Reaction equation

HRID 936487 reaction equation
[CH:19]([CH3:20])([CH3:21])[c:22]1[c:23]([C:27](=[O:28])[OH:29])[n:24][cH:25][o:26]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:7]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:7]1)[C:27]([c:23]1[c:22]([CH:19]([CH3:20])[CH3:21])[o:26][cH:25][n:24]1)=[O:28]

Participants

3

Reactant 2

HCID 134887995-(Propan-2-yl)-1,3-oxazole-4-carboxylic acidHCID 672347104-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-6H-1,3-oxazin-2-amine

Product 1

HCID 67234201N-[3-(2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl)-4-fluorophenyl]-5-propan-2-yl-1,3-oxazole-4-carboxamide

Sources & evidence

ORD record
ord-c728ada7c2a2428a9bbdf5136fc6e1e8
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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