ethyl 2-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate → 2-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylic acid

HRID 936504Notes

Reaction equation

HRID 936504 reaction equation
[CH2:1]([n:2]1[cH:3][c:4](-[c:5]2[s:6][c:7]([C:8]([O:9][CH2:10][CH3:11])=[O:12])[c:13]([CH3:14])[n:15]2)[n:16][n:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.[F:24][c:25]1[cH:26][cH:27][c:28]([CH2:29][n:30]2[n:31][n:32][c:33](-[c:35]3[s:36][c:37]([C:41](=[O:42])[O:43][CH2:44][CH3:45])[c:38]([CH3:40])[n:39]3)[cH:34]2)[cH:46][cH:47]1>>[F:24][c:25]1[cH:26][cH:27][c:28]([CH2:29][n:30]2[n:31][n:32][c:33](-[c:35]3[s:36][c:37]([C:41](=[O:42])[OH:43])[c:38]([CH3:40])[n:39]3)[cH:34]2)[cH:46][cH:47]1

Participants

3

Reactant 2

HCID 59179694ethyl 2-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylateHCID 59179723ethyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate

Product 1

HCID 591797032-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylic acid

Sources & evidence

ORD record
ord-ff6461be245a4457b86d7b8b01754b77
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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