3-(2-Methoxyethyl)-2,3,4,5-tetrahydro-1h-3-benzazepin-7-amine → 7-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ylamino]-pyrimidin-4-ylamino}-4-(4-isopropyl-piperazin-1-yl)-2-methyl-2,3-dihydro-isoindol-1-one
Reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][c:8]2[c:9]([cH:12][c:13]([NH2:16])[cH:14][cH:15]2)[CH2:10][CH2:11]1.[Cl:17][c:18]1[n:19][cH:20][c:21]([Cl:45])[c:22]([NH:24][c:25]2[cH:26][cH:27][c:28]([N:36]3[CH2:37][CH2:38][N:39]([CH:42]([CH3:43])[CH3:44])[CH2:40][CH2:41]3)[c:29]3[c:33]2[C:32](=[O:34])[N:31]([CH3:35])[CH2:30]3)[n:23]1>>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][c:8]2[c:9]([cH:12][c:13]([NH:16][c:18]3[n:19][cH:20][c:21]([Cl:45])[c:22]([NH:24][c:25]4[cH:26][cH:27][c:28]([N:36]5[CH2:37][CH2:38][N:39]([CH:42]([CH3:43])[CH3:44])[CH2:40][CH2:41]5)[c:29]5[c:33]4[C:32](=[O:34])[N:31]([CH3:35])[CH2:30]5)[n:23]3)[cH:14][cH:15]2)[CH2:10][CH2:11]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-9e9320dac0af42719ad89d0cedb7224d
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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