HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dimethoxybenzeneboronic acid → 8-(2,4-dimethoxyphenyl)-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dimethoxybenzeneboronic acid | HCID 2734341 | — |
| Reactant | 8-bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine | HCID 11174597 | — |
| Product | 8-(2,4-dimethoxyphenyl)-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine | HCID 21984368 | — |
Reaction Steps
8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and 2,4-dimethoxybenzeneboronic acid were coupled according to the general procedure described in Part J of Example 1. Purification by chromatography on silica gel (7% methanol in CH2Cl2) afforded 8-(2,4-dimethoxyphenyl)-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine as a white solid, m.p. 223–227° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07091214B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-5f0e7f0c7f184036b62819e4b30b2546 |
| Source note | uspto-grants-2006_08 |