Bicarbonate Ion → tert-Butyl 3-fluoropyrrolidine-1-carboxylate

HRID 937038Notes

Reaction equation

HRID 937038 reaction equation
[C:14](=[O:15])([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[N:21]1[CH2:22][CH:23]([OH:26])[CH2:24][CH2:25]1.[C:27](=[O:28])([O-:29])[OH:30].[CH3:1][O:2][CH2:3][CH2:4][N:5]([S:6]([F:7])([F:8])[F:11])[CH2:9][CH2:10][O:12][CH3:13].[Cl:32][CH2:33][Cl:34].[Na+:31]>>[F:11][CH:23]1[CH2:22][N:21]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:25][CH2:24]1

Participants

6

Reactant 5

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 2734690(Bis(2-methoxyethyl)amino)sulfur trifluorideHCID 44169391-Boc-3-pyrrolidinol

Product 1

HCID 25000885tert-Butyl 3-fluoropyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-4b5a0918238f4f958f7f52c4d6c728ad
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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