4-Hydroxypyrrolidine → 4-[[4-(3-Hydroxypyrrolidin-1-yl)-2-methylquinolin-7-yl]oxymethyl]benzonitrile
Reaction equation
[Cl:1][c:2]1[cH:3][c:4]([CH3:22])[n:5][c:6]2[cH:7][c:8]([O:12][CH2:13][c:14]3[cH:15][cH:16][c:17]([C:18]#[N:19])[cH:20][cH:21]3)[cH:9][cH:10][c:11]12.[OH:23][CH:24]1[CH2:25][NH:26][CH2:27][CH2:28]1>>[c:2]1([N:26]2[CH2:25][CH:24]([OH:23])[CH2:28][CH2:27]2)[cH:3][c:4]([CH3:22])[n:5][c:6]2[cH:7][c:8]([O:12][CH2:13][c:14]3[cH:15][cH:16][c:17]([C:18]#[N:19])[cH:20][cH:21]3)[cH:9][cH:10][c:11]12Participants
3
Sources & evidence
- ORD record
- ord-575061fa04ee4945b25dd844ebe721de
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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