Potassium Cation → tert-butyl 3-cyclohexyl-2-(2-hydroxyphenyl)-1-methyl-1H-indole-6-carboxylate

HRID 937048Notes

Reaction equation

HRID 937048 reaction equation
[Br:1][c:2]1[n:3]([CH3:24])[c:4]2[cH:5][c:6]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[cH:7][cH:8][c:9]2[c:10]1[CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1.[C:35](=[O:36])([O-:37])[O-:38].[CH3:42][O:43][CH2:44][CH2:45][O:46][CH3:47].[K+:39].[K+:40].[OH2:41].[OH2:48].[OH:25][c:26]1[c:27]([B:32]([OH:33])[OH:34])[cH:28][cH:29][cH:30][cH:31]1>>[c:2]1(-[c:27]2[c:26]([OH:25])[cH:31][cH:30][cH:29][cH:28]2)[n:3]([CH3:24])[c:4]2[cH:5][c:6]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[cH:7][cH:8][c:9]2[c:10]1[CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 962Water2×HCID 80711,2-DimethoxyethaneHCID 19660Carbonate IonHCID 2773454(2-Hydroxyphenyl)boronic acidHCID 58317838tert-butyl 2-bromo-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate

Product 1

HCID 58317805tert-butyl 3-cyclohexyl-2-(2-hydroxyphenyl)-1-methyl-1H-indole-6-carboxylate

Sources & evidence

ORD record
ord-badc2d7758d84313869879c345ab5087
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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