2-Fluoro-4-(trifluoromethyl)aniline → 6-Chloro-N-(2-fluoro-4-trifluoromethyl-phenyl)-nicotinamide

HRID 937129Notes

Reaction equation

HRID 937129 reaction equation
[Cl:13][c:14]1[n:15][cH:16][c:17]([C:18](=[O:19])[Cl:20])[cH:21][cH:22]1.[Cl:23][c:24]1[cH:25][cH:26][c:27]([C:28]([NH:29][c:30]2[cH:31][cH:32][c:33]([I:34])[c:35]([CH3:36])[cH:37]2)=[O:38])[cH:39][n:40]1.[F:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1>>[F:1][c:2]1[c:3]([NH:4][C:18]([c:17]2[cH:16][n:15][c:14]([Cl:13])[cH:22][cH:21]2)=[O:19])[cH:5][cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1

Participants

4

Reactant 3

HCID 27376742-Fluoro-4-(trifluoromethyl)anilineHCID 27821656-Chloronicotinoyl ChlorideHCID 593181386-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide

Product 1

HCID 593180766-Chloro-N-(2-fluoro-4-trifluoromethyl-phenyl)-nicotinamide

Sources & evidence

ORD record
ord-88e66984414f43829e46e8c63eea7f34
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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