(2RS,3RS)-3-amino-1-phenoxy-butan-2-ol → (2RS,3RS)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenoxy-butan-2-amine
Reaction equation
[F:14][c:15]1[cH:16][cH:17][c:18](-[n:21]2[n:22][cH:23][c:24]3[cH:25][c:26]([I:30])[cH:27][cH:28][c:29]23)[cH:19][cH:20]1.[NH2:1][CH:2]([CH:3]([CH2:4][O:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[OH:12])[CH3:13]>>[NH2:1][CH:2]([CH:3]([CH2:4][O:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[O:12][c:26]1[cH:25][c:24]2[cH:23][n:22][n:21](-[c:18]3[cH:17][cH:16][c:15]([F:14])[cH:20][cH:19]3)[c:29]2[cH:28][cH:27]1)[CH3:13]Participants
3
Sources & evidence
- ORD record
- ord-39a3189380514408b112a20ff1ca0f2e
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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