Dichloromethane → 4-[(5-Chloro-3-methyl-pyridin-2-ylmethyl)-(3-isopropyl-pyridin-2-ylmethyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

HRID 937492Notes

Reaction equation

HRID 937492 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([NH:14][CH2:15][c:16]2[n:17][cH:18][c:19]([Cl:23])[cH:20][c:21]2[CH3:22])[CH2:12][CH2:13]1.[CH:24]([CH3:25])([CH3:26])[c:27]1[c:28]([CH:33]=[O:34])[n:29][cH:30][cH:31][cH:32]1.[Cl:35][CH2:36][Cl:37]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]([CH2:15][c:16]2[n:17][cH:18][c:19]([Cl:23])[cH:20][c:21]2[CH3:22])[CH2:33][c:28]2[c:27]([CH:24]([CH3:25])[CH3:26])[cH:32][cH:31][cH:30][n:29]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 450836353-IsopropylpicolinaldehydeHCID 672718274-[(5-Chloro-3-methyl-pyridin-2-ylmethyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 672730144-[(5-Chloro-3-methyl-pyridin-2-ylmethyl)-(3-isopropyl-pyridin-2-ylmethyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-af47464a2c6d4851bec9abd670a8a485
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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