Ethanol → (1RS,2SR)-2-amino-3-[3-(neopentyloxy)phenyl]-1-(3-chlorophenyl)-1-propanol

HRID 937567Notes

Reaction equation

HRID 937567 reaction equation
[CH2:1]([C:2]([CH3:3])([CH3:4])[CH3:5])[O:6][c:7]1[cH:8][c:9]([CH2:10][CH:11]2[NH:12][C:13](=[O:23])[O:14][CH:15]2[c:16]2[cH:17][c:18]([Cl:22])[cH:19][cH:20][cH:21]2)[cH:24][cH:25][cH:26]1.[CH3:29][CH2:30][OH:31].[Na+:28].[OH-:27].[OH2:32]>>[CH2:1]([C:2]([CH3:3])([CH3:4])[CH3:5])[O:6][c:7]1[cH:8][c:9]([CH2:10][CH:11]([NH2:12])[CH:15]([OH:14])[c:16]2[cH:17][c:18]([Cl:22])[cH:19][cH:20][cH:21]2)[cH:24][cH:25][cH:26]1

Participants

6

Reactant 5

HCID 702EthanolHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 22261600(4RS,5SR)-4-[3-(neopentyloxy)benzyl]-5-(3-chlorophenyl)-1,3-oxazolidin-2-one

Product 1

HCID 22261929(1RS,2SR)-2-amino-3-[3-(neopentyloxy)phenyl]-1-(3-chlorophenyl)-1-propanol

Sources & evidence

ORD record
ord-7ff8fdef2136416fa1b40fa63b98b558
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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