Sodium ion → 2,2-Dimethylpropyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate

HRID 937692Notes

Reaction equation

HRID 937692 reaction equation
[Cl:18][c:19]1[c:20]2[c:21]([n:22][cH:23][n:24]1)[N:25]([c:28]1[c:29]([F:38])[cH:30][c:31]([S:34](=[O:35])(=[O:36])[CH3:37])[cH:32][cH:33]1)[CH2:26][CH2:27]2.[H-:17].[Na+:16].[OH:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][CH2:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:6][CH2:7]1>>[O:1]([CH:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][CH2:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:6][CH2:7]1)[c:19]1[c:20]2[c:21]([n:22][cH:23][n:24]1)[N:25]([c:28]1[c:29]([F:38])[cH:30][c:31]([S:34](=[O:35])(=[O:36])[CH3:37])[cH:32][cH:33]1)[CH2:26][CH2:27]2

Participants

5

Reactant 4

HCID 923Sodium ionHCID 166653HydrideHCID 426368224-Chloro-7-(2-fluoro-4-(methylsulfonyl)phenyl)-6,7-dihydro-5H-pyrrolo[2,3-D]pyrimidineHCID 688439722,2-Dimethylpropyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 441775892,2-Dimethylpropyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-809e36930db24ba4a9396ce7f482ef36
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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