1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 1-Ethyl-7-[2-(ethylaminomethyl)morpholin-4-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid
Reaction equation
[CH2:1]([CH3:2])[n:3]1[cH:4][c:5]([C:17](=[O:18])[OH:19])[c:6](=[O:16])[c:7]2[cH:8][c:9]([F:15])[c:10]([F:14])[c:11]([F:13])[c:12]12.[CH2:20]([CH3:21])[NH:22][CH2:23][CH:24]1[O:25][CH2:26][CH2:27][NH:28][CH2:29]1>>[CH2:1]([CH3:2])[n:3]1[cH:4][c:5]([C:17](=[O:18])[OH:19])[c:6](=[O:16])[c:7]2[cH:8][c:9]([F:15])[c:10]([N:28]3[CH2:27][CH2:26][O:25][CH:24]([CH2:23][NH:22][CH2:20][CH3:21])[CH2:29]3)[c:11]([F:13])[c:12]12Participants
3
Sources & evidence
- ORD record
- ord-0ce55333fdf0447cbd2686a119fc9faa
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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