Acetate → 3-(4-tert-Butyl-phenyl)-4-cyano-5-trifluoromethyl-thiophene-2-carboxylic acid ethyl ester
Reaction equation
[C:18]([CH3:19])([CH3:20])([CH3:21])[c:22]1[cH:23][cH:24][c:25]([B:28]([OH:29])[OH:30])[cH:26][cH:27]1.[C:39]([O-:40])(=[O:41])[CH3:42].[C:44]([O-:45])(=[O:46])[CH3:47].[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[s:7][c:8]([C:14]([F:15])([F:16])[F:17])[c:9]([C:12]#[N:13])[c:10]1[I:11].[CH3:33][O:34][CH2:35][CH2:36][O:37][CH3:38].[F-:31].[K+:32].[Pd+2:43]>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[s:7][c:8]([C:14]([F:15])([F:16])[F:17])[c:9]([C:12]#[N:13])[c:10]1-[c:25]1[cH:24][cH:23][c:22]([C:18]([CH3:19])([CH3:20])[CH3:21])[cH:27][cH:26]1Participants
8
Reactant 7
HCID 175Acetate2×
HCID 813Potassium Cation
HCID 80711,2-Dimethoxyethane
HCID 28179Fluoride Ion
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 27343204-tert-Butylphenylboronic acid
HCID 685208084-Cyano-3-iodo-5-trifluoromethyl-thiophene-2-carboxylic acid ethyl esterProduct 1
Sources & evidence
- ORD record
- ord-d7c669011ca347858519eb93b6284051
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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