Ethanol → tert-Butyl [(4-fluoropiperidin-4-yl)methyl]carbamate

HRID 938125Notes

Reaction equation

HRID 938125 reaction equation
[C:1](=[O:2])([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[N:9]1[CH2:10][CH2:11][C:12]([F:15])([CH2:16][NH:17][C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:13][CH2:14]1.[CH3:28][CH2:29][OH:30].[Na+:26].[OH-:25].[OH2:27]>>[NH:9]1[CH2:10][CH2:11][C:12]([F:15])([CH2:16][NH:17][C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:13][CH2:14]1

Participants

6

Reactant 5

HCID 702EthanolHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 67231354N-benzoyl-4-tert-butoxycarbonylaminomethyl-4-fluoropiperidine

Product 1

HCID 53415226tert-Butyl [(4-fluoropiperidin-4-yl)methyl]carbamate

Sources & evidence

ORD record
ord-292dc541b1b647cd8f9a5350462e11b2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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