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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 938294Generated: October 26, 2026

Hydrochloric Acid → 4-[4-cyano-2-(1,3-thiazol-4-ylmethylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4H-pyrimidine-5-carbonitrile

https://huagongshe.com/reaction/938294

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantPotassium CationHCID 813—
ReactantSodium ionHCID 923—
ReactantDimethylformamideHCID 6228—
ReactantCarbonate IonHCID 19660—
Reactant18-Crown-6HCID 28557—
ReactantIodide IonHCID 30165—
Reactant4-(Chloromethyl)-1,3-thiazoleHCID 2763290—
ReactantHCID 178428463HCID 178428463—
Product4-[4-cyano-2-(1,3-thiazol-4-ylmethylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4H-pyrimidine-5-carbonitrileHCID 68757211—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-64f8430662194852a539ce00822e6cf7
Source noteValidation data from https://doi.org/10.1039/C8SC04228D