Potassium Cation → Methyl 2-(3-fluoro-4-(trifluoromethyl)phenyl)isonicotinate

HRID 938504Notes

Reaction equation

HRID 938504 reaction equation
[C:12](=[O:13])([O-:14])[O-:15].[CH3:38][OH:39].[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[O:7][CH3:8])[cH:9][cH:10][n:11]1.[F:18][c:19]1[cH:20][c:21]([B:29]2[O:30][C:31]([CH3:32])([CH3:33])[C:34]([CH3:35])([CH3:36])[O:37]2)[cH:22][cH:23][c:24]1[C:25]([F:26])([F:27])[F:28].[K+:16].[K+:17].[Pd:40]([Cl:41])[Cl:42]>>[c:2]1(-[c:21]2[cH:20][c:19]([F:18])[c:24]([C:25]([F:26])([F:27])[F:28])[cH:23][cH:22]2)[cH:3][c:4]([C:5](=[O:6])[O:7][CH3:8])[cH:9][cH:10][n:11]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 887MethanolHCID 19660Carbonate IonHCID 24290Palladium ChlorideHCID 2736842Methyl 2-chloropyridine-4-carboxylateHCID 467390543-Fluoro-4-(trifluoromethyl)phenylboronic acid pinacol ester

Product 1

HCID 66732503Methyl 2-(3-fluoro-4-(trifluoromethyl)phenyl)isonicotinate

Sources & evidence

ORD record
ord-2b56f7ce3a8643809374853d08d08f72
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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