Methanol → 4-Methyl-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline
Reaction equation
[BH4-:22].[CH3:1][CH:2]1[CH2:3][N:4]=[C:5]([c:12]2[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]2)[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21.[CH3:24][OH:25].[Na+:23]>>[CH3:1][CH:2]1[CH2:3][NH:4][CH:5]([c:12]2[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]2)[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21Participants
5
Sources & evidence
- ORD record
- ord-fad873bc518143628d314df3d29e3718
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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