Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 938555Generated: October 27, 2026

Methanol → 4-(9'-cyclopentyl-5'-methyl-6'-oxo-5',6',8',9'-tetrahydrospiro[cyclopropane-1,7'-pyrimido[5,4-b][1,4]diazepine]-2'-ylamino)-N-(2,2-dimethyl-3-pyrrolidin-1-yl-propyl)-3-methoxy-benzamide

https://huagongshe.com/reaction/938555

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantWaterHCID 962—
Reactantp-Toluenesulfonic acidHCID 6101—
Reactant4-Methyl-2-PentanolHCID 7910—
Reactant2-chloro-9-cyclopentyl-8,9-dihydro-5-methylspiro[5H-pyrimido[4,5-b][1,4]diazepine-7,1'-cyclopropan]-6(7H)-oneHCID 57969939—
Reactant4-amino-N-(2,2-dimethyl-3-pyrrolidin-1-yl-propyl)-3-methoxy-benzamideHCID 68685881—
Product4-(9'-cyclopentyl-5'-methyl-6'-oxo-5',6',8',9'-tetrahydrospiro[cyclopropane-1,7'-pyrimido[5,4-b][1,4]diazepine]-2'-ylamino)-N-(2,2-dimethyl-3-pyrrolidin-1-yl-propyl)-3-methoxy-benzamideHCID 68686583—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-351149fb91994faa95bf4a0ec711d961
Source noteValidation data from https://doi.org/10.1039/C8SC04228D