6-Bromo-1-methylpyridin-2(1H)-one → 6-(3-Hydroxypropyl)-3-[1-[4-(1-methyl-6-oxo-2-pyridinyl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one

HRID 938778Notes

Reaction equation

HRID 938778 reaction equation
[Br:35][c:36]1[cH:37][cH:38][cH:39][c:40](=[O:43])[n:41]1[CH3:42].[OH:1][CH2:2][CH2:3][CH2:4][C:5]1([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[CH2:6][CH2:7][N:8]([CH:12]([CH3:13])[c:14]2[cH:15][cH:16][c:17]([B:20]3[O:21][C:22]([CH3:23])([CH3:24])[C:25]([CH3:26])([CH3:27])[O:28]3)[cH:18][cH:19]2)[C:9](=[O:11])[O:10]1>>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[CH2:6][CH2:7][N:8]([CH:12]([CH3:13])[c:14]2[cH:15][cH:16][c:17](-[c:36]3[cH:37][cH:38][cH:39][c:40](=[O:43])[n:41]3[CH3:42])[cH:18][cH:19]2)[C:9](=[O:11])[O:10]1

Participants

3

Reactant 2

HCID 8171686-Bromo-1-methylpyridin-2(1H)-oneHCID 723443116-(3-Hydroxypropyl)-6-phenyl-3-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]-1,3-oxazinan-2-one

Product 1

HCID 723443766-(3-Hydroxypropyl)-3-[1-[4-(1-methyl-6-oxo-2-pyridinyl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one

Sources & evidence

ORD record
ord-7bd6902fdcdd4e10b20dc59486201e9d
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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