Bicarbonate Ion → N-(3-(6-(4-methoxyphenyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-indol-3-yl)phenyl)acetamide

HRID 939067Notes

Reaction equation

HRID 939067 reaction equation
[C:46](=[O:47])([OH:48])[O-:49].[CH2:51]([Cl:52])[Cl:53].[CH3:1][C:2](=[O:3])[O:4][C:5](=[O:6])[CH3:7].[NH2:8][c:9]1[cH:10][c:11](-[c:15]2[cH:16][n:17](-[c:32]3[cH:33][c:34]([NH:38][CH3:39])[n:35][cH:36][n:37]3)[c:18]3[cH:19][c:20](-[c:24]4[cH:25][cH:26][c:27]([O:30][CH3:31])[cH:28][cH:29]4)[cH:21][cH:22][c:23]23)[cH:12][cH:13][cH:14]1.[Na+:50].[cH:40]1[cH:41][cH:42][n:43][cH:44][cH:45]1>>[CH3:1][C:2](=[O:3])[NH:8][c:9]1[cH:10][c:11](-[c:15]2[cH:16][n:17](-[c:32]3[cH:33][c:34]([NH:38][CH3:39])[n:35][cH:36][n:37]3)[c:18]3[cH:19][c:20](-[c:24]4[cH:25][cH:26][c:27]([O:30][CH3:31])[cH:28][cH:29]4)[cH:21][cH:22][c:23]23)[cH:12][cH:13][cH:14]1

Participants

7

Reactant 6

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 1049PyridineHCID 6344DichloromethaneHCID 7918Acetic AnhydrideHCID 509918426-(3-(3-aminophenyl)-6-(4-methoxyphenyl)-1H-indol-1-yl)-N-methylpyrimidin-4-amine

Product 1

HCID 50991843N-(3-(6-(4-methoxyphenyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-indol-3-yl)phenyl)acetamide

Sources & evidence

ORD record
ord-9e431b44229740e5a141460b8d5000df
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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