Acetate → Methyl 2-(butan-2-ylamino)-6-(2-oxopropyl)pyridine-4-carboxylate
Reaction equation
[C:62](=[O:63])([O-:64])[O-:65].[CH3:1][O:2][C:3]([c:4]1[cH:5][c:6]([Cl:14])[n:7][c:8]([CH2:10][C:11]([CH3:12])=[O:13])[cH:9]1)=[O:15].[CH3:73][c:74]1[cH:75][cH:76][cH:77][cH:78][cH:79]1.[CH3:80][CH2:81][O:82][CH2:83][CH3:84].[CH:68]([CH3:69])([CH2:70][CH3:71])[NH2:72].[Cs+:66].[Cs+:67].[O-:86][C:87]([CH3:88])=[O:89].[O-:90][C:91]([CH3:92])=[O:93].[Pd+2:85].[c:16]1([P:17]([c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)[c:24]2[cH:25][cH:26][c:27]3[c:28]([cH:29][cH:30][cH:31][cH:32]3)[c:33]2-[c:34]2[c:35]3[c:36]([cH:37][cH:38][cH:39][cH:40]3)[cH:41][cH:42][c:43]2[P:44]([c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)[cH:57][cH:58][cH:59][cH:60][cH:61]1>>[CH3:1][O:2][C:3]([c:4]1[cH:5][c:6]([NH:72][CH:68]([CH3:69])[CH2:70][CH3:71])[n:7][c:8]([CH2:10][C:11]([CH3:12])=[O:13])[cH:9]1)=[O:15]Participants
10
Reactant 9
HCID 175Acetate2×
HCID 1140Toluene
HCID 3283Diethyl Ether
HCID 19660Carbonate Ion
HCID 24874Sec-Butylamine
HCID 104967Cesium cation2×
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 634876Binap, (A+-)-
HCID 860813562-Chloro-6-(2-oxopropyl)-isonicotinic acid methyl esterProduct 1
Sources & evidence
- ORD record
- ord-e7b1c8a9eb6047909046bf6f1e3fcba3
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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