tert-Butyl bromoacetate → {6-Chloro-3-[4-(2-methoxy-phenyl)-piperidine-1-carbonyl]-indol-1-yl}-acetic acid tert-butyl ester
Reaction equation
[C:27]([CH3:28])([CH3:29])([CH3:30])[O:31][C:32]([CH2:33][Br:34])=[O:35].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11](=[O:12])[N:13]3[CH2:14][CH2:15][CH:16]([c:19]4[c:20]([O:25][CH3:26])[cH:21][cH:22][cH:23][cH:24]4)[CH2:17][CH2:18]3)[cH:7][nH:8][c:9]2[cH:10]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11](=[O:12])[N:13]3[CH2:14][CH2:15][CH:16]([c:19]4[c:20]([O:25][CH3:26])[cH:21][cH:22][cH:23][cH:24]4)[CH2:17][CH2:18]3)[cH:7][n:8]([CH2:33][C:32]([O:31][C:27]([CH3:28])([CH3:29])[CH3:30])=[O:35])[c:9]2[cH:10]1Participants
3
Sources & evidence
- ORD record
- ord-6cc31d4142e74c47b3531b56f0039397
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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