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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 939201Generated: October 30, 2026

Dimethylformamide → 4-Hydroxy-3-[4-(4-hydroxybut-1-ynyl)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

https://huagongshe.com/reaction/939201

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantDiethylamineHCID 8021—
ReactantTriphenylphosphineHCID 11776—
Reactant3-Butyn-1-OLHCID 13566—
ReactantPalladium ChlorideHCID 24290—
ReactantCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
Reactant3-(4-Bromophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrileHCID 54696423—
Product4-Hydroxy-3-[4-(4-hydroxybut-1-ynyl)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrileHCID 54689881—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-636d1e70a725492cb0d17dc2bbd3a6d9
Source noteValidation data from https://doi.org/10.1039/C8SC04228D