tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate → tert-butyl 4-[4-[6-(5-methoxy-2-oxospiro[1H-indole-3,2'-cyclopropane]-1'-yl)-1H-indazol-3-yl]phenyl]piperidine-1-carboxylate

HRID 939232Notes

Reaction equation

HRID 939232 reaction equation
[CH3:25][C:26]1([CH3:27])[C:28]([CH3:29])([CH3:30])[O:31][B:32]([c:33]2[cH:34][cH:35][c:36]([CH:39]3[CH2:40][CH2:41][N:42]([C:45](=[O:46])[O:47][C:48]([CH3:49])([CH3:50])[CH3:51])[CH2:43][CH2:44]3)[cH:37][cH:38]2)[O:52]1.[I:1][c:2]1[n:3][nH:4][c:5]2[cH:6][c:7]([CH:11]3[C:12]4([CH2:13]3)[C:14](=[O:24])[NH:15][c:16]3[cH:17][cH:18][c:19]([O:22][CH3:23])[cH:20][c:21]34)[cH:8][cH:9][c:10]12>>[c:2]1(-[c:33]2[cH:34][cH:35][c:36]([CH:39]3[CH2:40][CH2:41][N:42]([C:45](=[O:46])[O:47][C:48]([CH3:49])([CH3:50])[CH3:51])[CH2:43][CH2:44]3)[cH:37][cH:38]2)[n:3][nH:4][c:5]2[cH:6][c:7]([CH:11]3[C:12]4([CH2:13]3)[C:14](=[O:24])[NH:15][c:16]3[cH:17][cH:18][c:19]([O:22][CH3:23])[cH:20][c:21]34)[cH:8][cH:9][c:10]12

Participants

3

Reactant 2

HCID 53629760tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylateHCID 178487024HCID 178487024, compound

Product 1

HCID 123381570tert-butyl 4-[4-[6-(5-methoxy-2-oxospiro[1H-indole-3,2'-cyclopropane]-1'-yl)-1H-indazol-3-yl]phenyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-ddad2be38a1840518bd19377f2eec29e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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